Experimental and Modeled Data for pH-Modulated Imine Exchange Reactions

A 2026 dataset by Juan Ramirez on figshare contains experimental and mathematical modeling data for dynamic covalent chemistry. The work investigates the transfer of structural units through imine/amine exchanges (transiminations) in solution and under solvent-free conditions, modulated by pH stimuli. The dataset includes results for reactions involving pyridine-derived aldehydes with aromatic and aliphatic amines, complemented by equilibrium-constants-based mathematical models.

Use Cases

• Modeling pH-adaptive behavior of dynamic imine libraries based on equilibrium constants described in the work.
• Analyzing reaction yields for successive transimination sequences under solvent-free conditions.
• Studying the effect of acid/base triggers on the reversibility of bis-imine formation mentioned in the description.

Strengths

• Includes mathematical models for equilibrium composition and pH-adaptive behavior.
• Covers both solution-phase and solvent-free (green chemistry) experimental conditions.
• Dataset is openly available under a CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 16.9 MB size suggests a relatively small dataset.

Provenance

Source

figshare

Collection Method

Experimental chemistry work and mathematical modeling, as described.

Time Range

2026

Freshness

Last updated 2026-04-13 11:31:34.

Geography

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