Schistosoma mansoni Egg Secretome from Infected Mouse Liver and Intestine

149 parasite proteins form a conserved core set identified as the in vivo egg excretory/secretory repertoire. The dataset was generated by Lucie Jedličková using laser microdissection and high-resolution mass spectrometry on infected mouse tissues. Protein profiles varied markedly between liver and intestinal granulomas and between acute and chronic infection phases.

Use Cases

• Identify potential vaccine or drug targets based on the core set of 149 parasite proteins.
• Study tissue-specific host-pathogen interactions by comparing protein profiles from liver versus intestinal granulomas.
• Analyze temporal dynamics of infection by examining protein changes between acute and chronic phases.
• Investigate immunomodulation mechanisms based on proteins like omega-1 and IPSE found in acute liver samples.

Strengths

• Defines a specific core set of 149 parasite proteins representing an in vivo egg secretome.
• Provides spatially and temporally resolved data from two organs (liver, intestine) and two infection phases (acute, chronic).
• Uses a precise collection method (laser microdissection) to isolate periovular granuloma microenvironments.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is contained in a 799.9 KB DOCX file, suggesting limited scope and potential need for extraction to a structured format.

Provenance

Source

figshare

Collection Method

Laser microdissection of periovular granulomas from infected mouse liver and intestine, followed by high-resolution mass spectrometry.

Freshness

Last updated 2026-05-15 05:47:23; freshness should be verified.