Supplementary file 1_Understanding quantitative effects of anti-amyloid therapies on tau b

A 1.4 MB DOCX file authored by Hugo Geerts, last updated in April 2026, presents a quantitative systems pharmacology model for Alzheimer's Disease. The model accounted for 70% and 50% of the variance in observed plasma p-tau181 and Clinical Dementia Rating-Sum Of Boxes changes, respectively, across trials of seven amyloid antibodies. It provides antibody-specific normalized decreases in plasma p-tau181 and hypotheses on the impact of disease pathology and gender on functional outcomes.

Use Cases

• Optimizing clinical trial design for amyloid-tau combination therapies based on simulated biomarker changes.
• Predicting patient cognitive outcomes based on model-derived relationships between amyloid reduction, tau load, and neuronal pathology.
• Comparing the relative effects of different anti-amyloid antibodies (e.g., donanemab, aducanumab, lecanemab) on biomarker trajectories.
• Investigating hypotheses regarding disease pathology progression and gender effects on treatment outcomes mentioned in the results.

Strengths

• Model validation against clinical trial data, accounting for 70% of variance in plasma p-tau181 and 50% in CDR-SOB.
• Includes specific, quantified antibody effects (e.g., -75% plasma p-tau181 decrease for lecanemab).
• Released under a permissive CC-BY-4.0 license for broad reuse.

Limitations

• The primary data file is a DOCX document; underlying simulation data or column definitions are not provided.
• Row count and tabular data structure are unknown, limiting immediate analysis suitability.
• Freshness should be verified as the last update date is in the future (2026-04-30).

Provenance

Source

figshare

Collection Method

Computational simulation using a quantitative systems pharmacology model combined with a neuronal network model.

Time Range

Model insights derived from clinical trials of seven amyloid antibodies; specific trial dates not provided.

Freshness

Last updated 2026-04 30 07:35:27

Geography

null