Pomiferin Cytotoxicity and Oxidative Stress Meta-Analysis Results

A 17.7 KB DOCX file contains the supplementary data from a meta-analysis quantifying Pomiferin's therapeutic profile. The analysis reports a pooled geometric mean IC50 of 12.6 μM and synthesizes its effects on oxidative stress biomarkers like Catalase. The dataset was authored by Burcu Yuksel and shared under a CC BY 4.0 license in March 2026.

Use Cases

• Analyze the pooled geometric mean IC50 value of 12.6 μM to benchmark Pomiferin's baseline cytotoxicity across studies.
• Investigate the relationship between tumour type (e.g., Glioma/neurological models) and reported IC50 values using meta-regression results.
• Examine the synthesized data on Catalase activity and protein level changes to assess Pomiferin's modulation of oxidative stress biomarkers.
• Compare efficacy metrics between in vitro and in vivo models based on the p-value (p = 0.190) reported for model type.

Strengths

• Analysis follows PRISMA guidelines and uses advanced statistical methods like multilevel random-effects models and Cluster-Robust Variance Estimation (CR2).
• Provides a quantitative synthesis of Pomiferin's activity, reporting specific metrics like a pooled geometric mean IC50 of 12.6 μM (logIC50 = 2.53).
• Identifies statistically significant variations in efficacy by tumour type (p = 0.012) and effects on Catalase (p = 0.044 for activity).

Limitations

• The dataset is very small (17.7 KB), containing only summary-level results from the meta-analysis, not the underlying raw study data.
• The analysis notes current data limitations preclude establishing definitive biological equivalence between in vitro and in vivo models.
• As a supplementary file from a single meta-analysis, its scope is limited to the specific studies and biomarkers included in that review.

Provenance

Source

figshare, authored by Burcu Yuksel.

Collection Method

Systematic search and meta-analysis of studies from PubMed, Scopus, and Web of Science following PRISMA guidelines.

Freshness

Last updated March 2026.