Ursolic Acid Effects on Hepatic Injury via Arachidonic Acid Pathway

Figshare hosts supplementary data from a study investigating ursolic acid's mechanism in mitigating hepatic ischemia-reperfusion injury. The research employed a murine model, network pharmacology, non-targeted metabolomics, and molecular docking to identify key pathways. Wen Hou authored the work, which was last updated in April 2026.

Use Cases

• Validate predicted UA-PTGES protein binding interactions using molecular docking data.
• Analyze changes in serum AST and ALT levels to quantify ursolic acid's hepatoprotective effect.
• Study the downregulation of key metabolites prostaglandin H2 and prostaglandin E2 via metabolomics results.
• Investigate the modulation of the ALOX12/12(S)-HETE signaling axis as a central mechanism.
• Replicate the integrated multi-omics analysis linking UA effects to the arachidonic acid metabolic pathway.

Strengths

• Data integrates results from murine model experiments, network pharmacology, and non-targeted metabolomics.
• Experimental validation includes cellular thermal shift assay (CETSA) confirming direct protein binding.
• License is CC-BY-4.0, permitting reuse with attribution.

Limitations

• Dataset is a 4.8 MB DOCX file containing supplementary text, not structured data tables.
• Sample size is limited to a murine model study, not human clinical data.
• Specific row counts, column names, and raw numerical data are unavailable.

Provenance

Source

Figshare repository, authored by Wen Hou.

Collection Method

Generated from a study using murine HIRI model, multi-omics analysis, and molecular docking.

Freshness

Last updated April 2026.