VANGL1 Pan-Cancer Multi-Omics Analysis with Translational Validation

A pan-cancer analysis of VANGL1 across 33 tumor types using bulk transcriptomic, single-cell RNA sequencing, and spatial transcriptomic datasets. The dataset includes results from functional studies and experimental validation in cell lines, organoids, and xenografts. It was authored by Wei Zhou and last updated on 2026-05-29.

Use Cases

• Analyze VANGL1 expression patterns across 33 tumor types based on bulk transcriptomic data
• Investigate intercellular communication pathways between VANGL1+ malignant cells and stromal cells based on single-cell RNA-seq analysis
• Validate mechanistic links between VANGL1, Wnt/Notch/mTOR signaling, and cancer stemness based on functional studies

Strengths

• Analysis spans 33 distinct tumor types
• Integrates bulk transcriptomic, single-cell RNA-seq, and spatial transcriptomic data
• Includes experimental validation using three cell lines, patient-derived organoids, and xenografts

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data may reflect bias inherent to the specific platforms and methodologies used

Provenance

Source

figshare

Collection Method

Comprehensive pan-cancer analysis using public datasets and experimental validation

Freshness

Last updated 2026-05-29 04:45:08