Donor-Derived Cell-Free DNA in Kidney and Liver Transplant Recipients Over Two Years

Longitudinal data from the first 2 years post-transplantation for kidney and liver recipients, collected by Fanny Sandberg and published in 2026. It includes absolute and relative quantities of donor-derived cell-free DNA (ddcfDNA) measured in plasma and urine via droplet digital PCR, using mismatched HLA-DRB1 alleles. The study investigates intra- and inter-individual variability of ddcfDNA to inform allograft injury detection.

Use Cases

• Modeling intra-individual variability of ddcfDNA to establish personalized rejection thresholds based on longitudinal dynamics mentioned in the description
• Comparing the diagnostic utility of absolute (ddcfDNA_cpml) versus relative (ddcfDNA%) quantities for liver transplant monitoring as discussed in the conclusions
• Analyzing inter-sex variability in urinary ddcfDNA fractional quantities in kidney transplant recipients as noted in the results

Strengths

• Longitudinal data covering the first 2 years post-transplantation for two organ types.
• Includes paired measurements of ddcfDNA in both plasma and urine for kidney recipients.
• Uses a specific molecular method (droplet digital PCR) targeting mismatched HLA-DRB1 alleles.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is a 2.1 MB PDF, suggesting it may be a supplementary results file rather than raw structured data.

Provenance

Source

figshare

Collection Method

Blood and urine samples collected longitudinally at regular clinical visits, with ddcfDNA quantified via droplet digital PCR.

Time Range

First 2 years post-transplantation.

Freshness

Last updated 2026-06-02 05:26:36; freshness should be verified.