VEGFR-1 Knockdown Effects on Neuronal Cell Death in Alzheimer's Disease Models

Supplementary file 1 from a study exploring the role of Vascular Endothelial Growth Factor Receptor-1 (VEGFR-1) in Alzheimer's Disease pathogenesis. The 700.7 KB PDF, authored by Debabrata Mukhopadhyay and last updated in May 2026, contains results from experiments on SH-SY5Y human neuroblastoma cells and mouse primary neurons exposed to hypoxia and Aβ1-42 oligomers/fibrils. The data likely includes differential gene expression analysis, immunostaining results, and protein level measurements related to VEGFR-1 knockdown.

Use Cases

• Analyzing differential gene expression patterns in response to Aβ1-42 oligomer treatment based on the description.
• Studying the relationship between VEGFR-1 expression and activation of inflammatory or cell death pathways mentioned in the results.
• Investigating the protective effects of VEGFR-1 knockdown against hypoxia-induced neuronal toxicity as described.
• Correlating protein level changes (e.g., cleaved caspase 3) with specific treatments like Aβ1-42 fibrils or monomers.

Strengths

• Data is derived from controlled experiments on both a human neuroblastoma cell line (SH-SY5Y) and mouse primary neurons.
• The study investigates multiple AD-relevant stressors: hypoxia, Aβ1-42 oligomers, and Aβ1-42 fibrils.
• Results include multiple analysis methods: immunostaining, differential gene expression, and protein level assays.

Limitations

• The dataset is a single 700.7 KB PDF file; the underlying raw data tables or matrices are not directly accessible.
• Row count and column-level documentation are unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

figshare, author Debabrata Mukhopadhyay.

Collection Method

Experimental data from immunostaining of AD brain sections and laboratory treatments of neuronal cell cultures.

Freshness

Last updated 2026-05-29 06:16:52; freshness should be verified.