Mesobuthus crucittii Venom Gland Transcriptome and Bioactivity Data

An Iranian endemic scorpion, Mesobuthus crucittii, provides the source for this venom gland transcriptome and bioactivity dataset. The data includes in silico analyses of a novel hyaluronidase sequence, molecular docking results, and experimental enzymatic assays. The dataset was authored by Masoumeh Baradaran and last updated on 2026-06-01.

Use Cases

• Phylogenetic analysis of venom enzymes based on the described hyaluronidase precursor sequence.
• Structural modeling of glycosyl hydrolase family 56 enzymes based on the reported catalytic and binding domains.
• Substrate specificity prediction based on molecular docking results for hyaluronic acid and chondroitin sulfate.
• Comparative analysis of toxin repertoires based on the described transcriptomic profile dominated by ion channel modulators.

Strengths

• The dataset includes a novel hyaluronidase precursor sequence with a unique cysteine framework of six disulfide bonds.
• Functional assays confirmed strong hyaluronan degradation and slower chondroitin sulfate hydrolysis, indicating dual substrate activity.
• Molecular docking results are included, supporting preferential binding affinity toward specific glycosaminoglycans.

Limitations

• The dataset is small at 1.4 MB, which may limit the scope of analysis.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Venom gland transcriptome profiling, in silico sequence analysis, molecular docking, and turbidimetric enzymatic assays.

Freshness

Last updated 2026-06-01 04:19:04; freshness should be verified.

Geography

Iran (source scorpion is Iranian endemic)