Supplementary file 1_Viscoelastic properties of sodium hyaluronate and their mathematical

A 2026 study by Horacio Rivarola presents a validated biomechanical and mathematical model for predicting the clinical efficacy of intra-articular sodium hyaluronate injections in osteoarthritis. The model, validated against clinical outcomes from 126 knee osteoarthritis patients, identifies an optimal viscoelastic window associated with superior clinical improvement. The research is published as a supplementary document on figshare under a CC-BY-4.0 license.

Use Cases

• Training predictive models for clinical outcomes based on viscoelastic properties and patient phenotypes mentioned in the description.
• Analyzing the relationship between molecular weight, concentration, and joint-specific mechanical demands for therapy optimization.
• Validating finite element model simulations of intra-articular fluid behavior against retrospective clinical data.
• Identifying optimal rheological parameters for joint-specific tailoring of viscosupplementation therapies.

Strengths

• Model validated against clinical outcomes from 126 knee osteoarthritis patients.
• Predictive accuracy of the model is reported (R² = 0.61; RMSE = 7.8).
• Specific optimal viscoelastic parameters are identified (G′ = 120–220 Pa, η = 50–120 Pa·s, tan δ = 0.4–0.6).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data file is a DOCX document, which may require extraction of underlying data.

Provenance

Source

figshare, authored by Horacio Rivarola.

Collection Method

Research involving predictive simulation modeling and retrospective clinical validation.

Time Range

Study dated 2026; specific temporal coverage of underlying data is not provided.

Freshness

Last updated 2026-04-13 05:45:19.

Geography

Spatial coverage is not specified.