Supplementary file 1_Vitamin D metabolites reshape bovine mammary epithelial responses rel

Georgina Tiraboschi published this dataset on 2026-05-01. It contains proteomic and functional data from an in vitro study comparing vitamin D3 metabolites. The data supports findings on host-directed mechanisms for managing bovine mastitis.

Use Cases

• Compare the effects of different vitamin D metabolites on cellular tolerance based on the description of D and 25D treatment.
• Analyze proteomic signatures related to epithelial homeostasis and innate immunity based on the 2,203 common proteins identified.
• Investigate the regulation of vitamin D metabolism enzymes like 24-hydroxylase based on transcriptional data mentioned.
• Study the reduction of Staphylococcus aureus internalization in epithelial cells based on pretreatment results with 25D.

Strengths

• Proteomic profiling identified 2,203 proteins common to all experimental conditions.
• The dataset is published under a CC-BY-4.0 license, allowing for broad reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small at 167.4 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Integrated in vitro approach using bovine mammary epithelial MAC-T cells, assessing antimicrobial activity, proteomics, and pathogen internalization.

Freshness

Last updated 2026-05-01 05:27:47; freshness should be verified.