FCRL3 Gene Variants and Rheumatoid Arthritis Risk in an Indian Population

A 2026 study by Mohamed Muzammil S presents genetic data from 226 Indian rheumatoid arthritis patients and 239 controls. It explores the association of four FCRL3 gene variants with disease susceptibility, validated by genotyping and in-silico molecular dynamics simulations. The dataset is shared under a CC-BY-4.0 license.

Use Cases

• Assessing genetic risk factors for rheumatoid arthritis based on FCRL3 SNP data.
• Conducting replication studies for SNP-disease associations in non-European populations.
• Training models for predicting disease susceptibility from specific genotypes.
• Benchmarking in-silico molecular docking and dynamics results against experimental genetic data.

Strengths

• Includes data from a specific cohort of 226 patients and 239 controls.
• Analysis covers four specific SNPs (rs7522061, rs11264799, rs11264797, rs7549100) with validated genotyping.
• Provides detailed statistical results, including odds ratios and p-values for associations.

Limitations

• The dataset is very small at 17.5 KB; row and column counts are unknown.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect geographic bias inherent to the single Indian cohort studied.

Provenance

Source

Mohamed Muzammil S via figshare.

Collection Method

Genotyping via High-Resolution Melting Analysis and Sanger sequencing, with statistical and computational analysis.

Freshness

Last updated 2026-06-03 08:04:32; freshness should be verified.

Geography

Indian population.