Gut Microbiota and Clinical Data from a Pediatric Henoch–Schönlein Purpura Treatment Study

A 2026 study by Kefei Xu includes data from 142 initially enrolled children, with 112 participants in the final clinical analysis. It contains clinical efficacy and gut microbiota profiling data from a trial comparing integrated Chinese and Western medicine to Western medicine alone for pediatric Henoch–Schönlein purpura. Gut microbiota was analyzed from 78 stool samples using 16S rRNA gene sequencing on an Illumina NovaSeq 6000.

Use Cases

• Training machine learning models to classify patient groups based on discriminatory genera like Lachnoclostridium and Ruminococcus.
• Analyzing treatment-related changes in microbial diversity using alpha and beta diversity metrics.
• Investigating functional pathway alterations via predicted KEGG pathways such as polyketide sugar unit biosynthesis.
• Comparing microbiota restoration profiles between integrated and Western medicine treatment groups.

Strengths

• Includes 78 stool samples sequenced in a single Illumina NovaSeq 6000 run to minimize batch effects.
• Multivariate analyses (PERMANOVA) adjusted for age, sex, and baseline diversity to isolate treatment effects.
• Clinical analysis includes 112 participants (39 healthy controls, 38 integrated treatment, 35 Western medicine).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 17.1 KB, indicating limited scope.

Provenance

Source

figshare, author Kefei Xu.

Collection Method

Data collected from a clinical trial with fecal samples analyzed via 16S rRNA gene sequencing.

Freshness

Last updated 2026-05-14 05:23:42; freshness should be verified.