Complement-Mediated ADCP Cytotoxicity Data for Therapeutic Antibodies

A 1.3 MB PDF file authored by Carly M. Van Wagoner and last updated on April 13, 2026, presents research on antibody-dependent cellular phagocytosis (ADCP). The study analyzes the kinetics, capacity, and exhaustion behavior of Fcγ receptor-dependent and complement-dependent ADCP pathways in primary mouse macrophages using quantitative live-cell imaging.

Use Cases

• Modeling the temporal dynamics of complement-mediated ADCP based on the described distinct kinetics.
• Investigating macrophage phagocytic exhaustion based on the described dose-dependent states for both pathways.
• Comparing the additive effects of Fcγ and complement pathways on target cell clearance as described in the results.
• Analyzing the reversibility of complement-associated phagocytic exhaustion based on the 24-hour recovery timeframe mentioned.

Strengths

• Data is openly licensed under CC-BY-4.0, permitting reuse with attribution.
• The research provides a direct comparison of two distinct phagocytic pathways using primary cells and live-cell imaging.

Limitations

• The dataset is a 1.3 MB PDF; underlying quantitative data or column definitions are not directly accessible.
• Row count and data structure are unknown, which may limit suitability assessment for computational analysis.
• The data is derived from a mouse model, which may limit direct translation to human immunology.

Provenance

Source

Carly M. Van Wagoner via figshare.

Collection Method

Quantitative live-cell imaging of primary mouse macrophages, with genetic and pharmacological pathway modulation.

Time Range

The experimental timeframe is not specified.

Freshness

Last updated 2026-04-13 05:48:24.

Geography

The geographic origin of the research is not specified.