Complement Response to Burn Injury: Meta-Analysis of 110 Studies

110 studies, including 73 for meta-analysis, were systematically reviewed to characterize complement activation dynamics after burn injury. The dataset, compiled by Patrick P. G. Mulder and updated in March 2026, contains quantitative results from human and animal studies across predefined time intervals. It provides aggregated findings on complement factors like C3a, C5a, and membrane attack complex.

Use Cases

• Modeling the temporal dynamics of complement activation based on reported outcomes across six post-burn time intervals.
• Analyzing heterogeneity in immune response based on variations in burn size, depth, and etiology mentioned in the description.
• Assessing risk of bias in preclinical and clinical studies using the SYRCLE and ROBANS-II tools referenced.
• Investigating correlations between specific complement factors (e.g., C3a, C5a, MAC) and clinical outcomes in burn pathology.

Strengths

• Aggregates data from 110 studies, providing a quantitative synthesis of a heterogeneous research field.
• Includes predefined subgroup analyses for six distinct time intervals post-injury, enabling longitudinal assessment.
• Openly licensed under CC-BY-4.0, facilitating reuse and redistribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• The included studies show substantial underreporting of methodological details, resulting in predominantly unclear or high risk of bias.
• Row count is unknown, which may limit suitability assessment for certain analytical tasks.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of studies from PubMed and Embase searched on February 20th, 2025.

Time Range

Studies encompass a wide range of publication dates, with the review search conducted in 2025.

Freshness

Last updated 2026-03-17 13:07:28; freshness should be verified.

Geography

Likely global, encompassing diverse animal models and human patient cohorts, but specific geography is not stated.