Network Meta-Analysis of Vitamin D Combination Therapies for Pediatric Rickets

Yunfeng Cao's supplementary document contains results from a Bayesian network meta-analysis comparing nine vitamin D-based combination regimens for nutritional rickets. The analysis synthesizes data from 10 randomized controlled trials involving 867 children. The study protocol was registered in PROSPERO and the document was last updated in April 2026.

Use Cases

• Compare relative efficacy rankings of nine vitamin D combination regimens on serum 25-hydroxyvitamin D levels.
• Assess safety profiles of different combination therapies using adverse event data from included trials.
• Analyze subgroup differences in treatment effects between term and preterm infant populations.
• Validate findings through sensitivity analysis results reported in the document.

Strengths

• Analysis based on 10 randomized controlled trials, a standard for clinical evidence synthesis.
• Includes data from 867 pediatric patients across the included studies.
• Study protocol was prospectively registered in PROSPERO (CRD420251029274), enhancing transparency.

Limitations

• The dataset is a 657.1 KB DOCX file containing textual results, not structured numerical data for direct computational analysis.
• Limited to 867 patients, which may constrain the statistical power for some subgroup comparisons.
• Relies on aggregated, published trial results rather than individual patient-level data.

Provenance

Source

Yunfeng Cao, published on figshare.

Collection Method

Systematic review and Bayesian network meta-analysis of trials from PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang, and VIP databases.

Time Range

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Freshness

Document last updated April 2026.

Geography

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