Efavirenz Metabolism and CNS Toxicity in Ugandan Children: CYP2B6 Genotype Impact

A 2015–2016 prospective study followed 99 ART-naïve Ugandan children aged 3–12 years, with plasma sampling at 2, 6, 12, and 24 weeks after initiating efavirenz-based therapy. Sandra Soeria-Atmadja authored this research quantifying efavirenz and its metabolites in plasma and exploring associations with CYP2B6 metabolizer phenotypes and CNS adverse effects. The dataset likely contains longitudinal measurements of drug and metabolite concentrations, genotype data, and questionnaire responses.

Use Cases

• Modeling the relationship between CYP2B6 genotype and efavirenz metabolite ratios based on described plasma measurements.
• Investigating associations between high efavirenz plasma concentrations (>4,000 ng/mL) and CNS symptoms based on the questionnaire data.
• Studying the autoinduction of efavirenz metabolism over time in extensive metabolizers using the longitudinal sampling design.
• Analyzing the distribution of conjugated versus unconjugated metabolite forms across different metabolizer phenotypes.

Strengths

• Includes data from 99 pediatric patients, a specific and often understudied population.
• Features longitudinal plasma sampling at four time points (2, 6, 12, and 24 weeks) to track changes.
• Quantifies multiple efavirenz metabolites (8-OH-EFV, 7-OH-EFV, EFAdeg) in both conjugated and unconjugated forms.

Limitations

• Row count and column-level documentation are unknown, which limits suitability assessment.
• The dataset is small (29.7 KB), indicating limited scope, likely summary statistics or a supplementary document rather than raw patient-level data.
• Data is specific to Ugandan children from 2015–2016; generalizability to other populations or time periods may be limited.

Provenance

Source

Sandra Soeria-Atmadja

Collection Method

Prospective clinical study using liquid chromatography high-resolution tandem mass spectrometry for quantification and genotyping for CYP2B6 and CYP2A6 SNPs.

Time Range

2015–2016

Freshness

Last updated 2026-04-24 05:40:35; freshness should be verified.

Geography

Uganda