Supplementary file 2_Effect of acupuncture on monoaminergic neurotransmitters in animal mo

Nine studies involving 386 rodents were included in this systematic review and meta-analysis. The data, compiled by Lixiang Gan and published on figshare in 2026, synthesizes findings from randomized controlled animal studies on acupuncture for vascular dementia. It reports standardized mean differences for neurotransmitters like serotonin, norepinephrine, and dopamine, as well as behavioral outcomes.

Use Cases

• Conducting secondary meta-analyses based on the reported standardized mean differences for neurotransmitters.
• Investigating the relationship between monoaminergic systems and cognitive function in animal models.
• Designing new preclinical studies on vascular dementia by referencing the included study characteristics and outcomes.
• Analyzing the heterogeneity and methodological quality of preclinical research in complementary medicine.

Strengths

• Follows PRISMA 2020 guidelines and is registered with PROSPERO (CRD420251179267), indicating a structured methodology.
• Reports specific quantitative results, including standardized mean differences for five key outcome measures (e.g., SMD = 4.75 for LTP).
• Includes a risk-of-bias assessment using the SYRCLE tool.

Limitations

• The underlying data file is a 159.3 KB DOCX document; column-level documentation and raw data are absent.
• The authors note substantial heterogeneity and small sample sizes across the included studies.
• Row count is unknown, which may limit suitability assessment for computational analysis.

Provenance

Source

Lixiang Gan via figshare.

Collection Method

Systematic review and meta-analysis of randomized controlled animal studies identified from eight English and Chinese databases.

Time Range

Literature search conducted from database inception to October 2025.

Freshness

Last updated 2026-05-11 04:24:34