Zishen Yutai Pill Effects on IVF Pregnancy Outcomes: Meta-Analysis of 18 RCTs

Eighteen randomized controlled trials with 5,660 participants were included in this systematic review and meta-analysis. The study evaluates the effect of the Chinese polyherbal preparation Zishen Yutai Pill on pregnancy outcomes for women undergoing in vitro fertilization-embryo transfer. The dataset, authored by Haifeng Wu and last updated in April 2026, contains the supplementary document for the analysis, including pooled results for clinical pregnancy rate, live birth rate, and other secondary outcomes.

Use Cases

• Conducting secondary analysis of meta-analytic results based on the reported risk ratios and mean differences.
• Assessing methodological quality and risk of bias in included studies based on the described ROB2 and GRADE evaluations.
• Investigating the safety profile of herbal interventions in IVF based on the reported adverse event rates.
• Designing future clinical trials based on the identified evidence gaps and heterogeneity mentioned in the conclusion.

Strengths

• Systematic review protocol was pre-registered with PROSPERO (CRD420251030089).
• Analysis includes data from 18 randomized controlled trials and 5,660 total participants.
• Used multiple tools for quality assessment (ROB2, GRADE) and bias evaluation (Egger’s test, funnel plots).

Limitations

• The GRADE assessment indicated the quality of evidence for all outcomes was very low.
• Only 5 of the 18 included studies reported on adverse events, limiting safety conclusions.
• The dataset is a 16.2 KB DOCX file; the underlying structured data (e.g., forest plot data) is not directly provided.

Provenance

Source

figshare, author Haifeng Wu

Collection Method

Systematic review and meta-analysis of RCTs sourced from databases including PubMed, Cochrane Library, Embase, Web of Science, CNKI, Wanfang, VIP, and CBM.

Time Range

Literature searched from database inception to 12 February 2025.

Freshness

Last updated 2026-04-23 05:34:46