Supplementary file 2_Exercise-induced changes in systemic inflammatory biomarkers in overw

25 meta-analyses encompassing 342 randomized controlled trials and over 30,000 participants form the core of this umbrella review. The study, published by Lei Chen in 2026, integrates bibliometric analysis of 12,101 records with a systematic review to evaluate the certainty of evidence for exercise's effects on biomarkers like CRP and IL-6. It provides pooled effect sizes and GRADE assessments for 10 different systemic inflammatory markers.

Use Cases

• Identify the most consistently exercise-responsive inflammatory biomarkers based on the reported standardized mean differences and evidence classes.
• Analyze global research trends and knowledge structure in exercise immunology using the bibliometric data mentioned.
• Assess the methodological quality and overlap of existing meta-analyses in this field using the described AMSTAR-2 and ROBIS tools.
• Inform the design of future clinical trials by highlighting biomarkers with insufficient evidence, such as IL-6 and adiponectin.

Strengths

• Evidence is synthesized from a large scale of primary research, including 342 RCTs and over 30,000 participants.
• Provides quantitative effect estimates (SMDs with 95% CIs) for 10 specific biomarkers, including CRP, IL-1β, and TNF-α.
• Applies a rigorous, multi-framework methodology for quality appraisal (AMSTAR-2, ROBIS, GRADE) to assess evidence certainty.
• Integrates two complementary analytical approaches: bibliometric mapping and an umbrella review of meta-analyses.

Limitations

• The dataset is a single PDF document; the underlying tabular data for the 12,101 bibliometric records or the 25 meta-analyses is not provided in a machine-readable format.
• Row count for the primary data is unknown, which may limit suitability assessment for computational analysis.
• Column-level documentation for any underlying data is absent; field semantics must be inferred from the manuscript.

Provenance

Source

figshare, authored by Lei Chen.

Collection Method

Bibliometric data retrieved from Web of Science Core Collection; meta-analyses identified via a comprehensive search of five databases through December 1, 2025.

Time Range

Bibliometric analysis covers 2005 to 2025; literature search for the umbrella review was conducted through December 1, 2025.

Freshness

Last updated 2026-05-20 05:47:53.