Shenzhen Neonatal Stroke Registry: Protocol for a 300-Patient Cohort Study, 2025-2030

Shenzhen, China, will host a multicenter, prospective, observational cohort study enrolling 300 neonates diagnosed with stroke between January 2025 and December 2020. The study protocol details the establishment of an online registry to collect data on incidence, risk factors, and long-term neurodevelopmental outcomes until age five. Author Xiaoli Zhao published the protocol on figshare under a CC-BY-4.0 license.

Use Cases

• Estimating the incidence of neonatal stroke based on registry data from 22 hospitals.
• Identifying prenatal and perinatal risk factors associated with different stroke subtypes.
• Developing prognostic models for motor outcomes based on integrated assessments like MRI, GMA, and HINE.
• Analyzing the metabolic-inflammatory nexus of neonatal injury using linked placental pathology and biobank samples.

Strengths

• Protocol outlines a planned enrollment of 300 patients from a network of 22 hospitals.
• Longitudinal follow-up is planned until age five, with standardized assessments including Bayley Scales, 3T MRI, and video-EEG.
• The study integrates clinical data with placental pathology and a biobank of stool and breast milk samples.

Limitations

• The dataset is a 17.9 KB protocol document (DOCX), not the actual clinical registry data.
• Row count and column-level documentation for the eventual registry data are unknown.
• The data collection period (2025-2030) is in the future; actual patient data is not yet available.

Provenance

Source

figshare

Collection Method

Data collection will utilize standardized electronic case report forms (eCRFs) via a digital system, transitioning to a secure web-based registry.

Time Range

Planned data collection from January 2025 to December 2030, with follow-up until participant age five.

Freshness

Last updated 2026-05-08 09:41:05.

Geography

Shenzhen, China.