Poge Heart-Saving Decoction Metabolite and Mouse Model Data

Figshare hosts a supplementary document detailing a study on Poge Heart-Saving Decoction (PHSD) and its effects on heart failure. The research identified 133 metabolites in PHSD and used a mouse model to analyze cardiac function, apoptosis, and fibrosis markers. The work was authored by Lei Du and published in 2026.

Use Cases

• Analyze the list of 133 identified PHSD metabolites for potential bioactive compound discovery.
• Examine the relationship between protein expression levels of BAX and BCL-2 in the context of ISO-induced myocardial apoptosis.
• Study the downregulation of PI3K and AKT expression data to validate the proposed therapeutic pathway inhibition.
• Review histopathological examination data on Collagen I and Collagen III deposition to assess fibrosis reduction.

Strengths

• The study provides a specific count of 133 metabolites identified in the PHSD formulation.
• Experimental data includes multiple treatment doses (low, medium, high) for the mouse model.
• Findings are supported by multiple analysis methods, including UHPLC-MS/MS, network analysis, echocardiography, and histopathology.

Limitations

• The primary data is embedded within a 24.4 KB DOCX file, not in a structured, machine-readable tabular format.
• The dataset scope is limited to the specific experimental results of one study, with no independent replication data.
• Sample sizes for the mouse model groups and raw numerical results are not explicitly provided in the description.

Provenance

Source

Figshare, authored by Lei Du.

Collection Method

Data generated from laboratory experiments including UHPLC-MS/MS metabolite characterization, network analysis, and in vivo mouse model studies.

Freshness

Last updated in March 2026.