Preclinical Meta-Analysis of Moringa Oleifera for Peptic Ulcer Disease

Systematic review and meta-analysis of 11 preclinical studies involving 268 animals, evaluating the therapeutic effect of Moringa oleifera extracts on peptic ulcer disease. It includes pooled analysis results, such as standard mean difference (SMD) and confidence intervals, for ulcer index reduction. The review was conducted by Saheed Olatunbosun Akiode and published in March 2026.

Use Cases

• Analyze the relationship between Moringa oleifera dose and ulcer index reduction using the reported standard mean difference (SMD) values.
• Assess methodological heterogeneity across the 11 included studies by examining SYRCLE quality scores and I² statistics.
• Compare the therapeutic efficacy of Moringa oleifera against standard drug controls using the subgroup analysis results for high-dose comparisons.
• Investigate publication bias in preclinical research using the Egger’s regression and trim-and-fill methods described in the meta-analysis.

Strengths

• Includes data from 11 studies and 268 animals, providing a quantitative synthesis of preclinical evidence.
• Reports specific meta-analysis metrics, including Hedge’s g, SMD with 95% confidence intervals, and I² for heterogeneity.
• Undertook sensitivity and subgroup analyses (e.g., by dose and comparator) to explore variability in outcomes.
• Documented systematic review registration (CRD420251080346) and used multiple database searches without a time filter.

Limitations

• Limited to 11 preclinical studies, a small sample size for meta-analysis that may affect generalizability.
• Findings are restricted to rodent models and have not been validated in clinical trials.
• High heterogeneity (I² = 69%) was noted in some subgroup analyses, indicating variability in study outcomes.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of randomized controlled animal experiments from PubMed, CINAHL, Scopus, Web of Science, and Cochrane Library.

Time Range

Studies from database inception to August 2025.

Freshness

Last updated March 2026.