Shenfu Injection in Sepsis-Induced Gastrointestinal Injury: A Narrative Review

A 2026 narrative review by Xiufeng Pang summarizes mechanistic and clinical evidence on Shenfu Injection for sepsis-induced acute gastrointestinal injury. The review is published as a 91.3 KB PDF file under a CC-BY-4.0 license on figshare. It aggregates findings from a structured search of English- and Chinese-language databases, covering preclinical and clinical studies.

Use Cases

• Summarize the mechanistic basis of Shenfu Injection based on its described anti-inflammatory and barrier-protective effects.
• Critically appraise clinical evidence for a botanical drug based on the review's analysis of study limitations like small sample sizes.
• Identify research gaps for sepsis treatment based on the review's conclusion that high-quality multicenter trials are needed.

Strengths

• The review covers both English and Chinese language sources, potentially reducing language bias.
• It provides a structured analysis of multiple biological pathways, including TLR4/NF-κB signaling and tight junction proteins.

Limitations

• The dataset is a single PDF file (91.3 KB), representing a limited textual scope.
• Row count and column-level documentation are absent; the content is narrative rather than structured data.
• The review itself notes that included clinical studies have constraints like small sample sizes and single-center designs.

Provenance

Source

Xiufeng Pang

Collection Method

Structured literature search of major English- and Chinese-language databases.

Freshness

Last updated 2026-05-01 05:27:47.