SHP2 in TAMs: RNA-seq and Cell Culture Data on Gastric Adenocarcinoma Survival

Supplementary file 2 from a study investigating how SHP2 in tumor-associated macrophages promotes gastric adenocarcinoma survival. The data likely contains results from bulk RNA-seq analysis of the GSE118916 dataset and experimental data from co-culture models of THP-1 and AGS cells under hypoxic conditions. Author Jing Bai uploaded the 12.8 MB PDF file to figshare under a CC-BY-4.0 license, with a last update timestamp of 2026-04-30.

Use Cases

• Identify differentially expressed genes in gastric cancer based on bulk RNA-seq analysis mentioned in the description.
• Study the correlation between macrophage infiltration and other immune cells like activated dendritic cells based on the immune infiltration analysis.
• Investigate the effects of SHP2, SP1, and BRD4 modulation on protein expression (e.g., p-P38, STING, Arg-1) and cancer cell phenotypes based on the experimental methods.
• Analyze pathway enrichment in extracellular matrix organization and adhesion based on the GO and KEGG analysis results.

Strengths

• Data is associated with a specific, detailed biological study investigating SHP2's role in macrophage polarization and gastric cancer.
• The description references analysis of a public dataset (GSE118916 from GEO) and controlled cell culture experiments, suggesting a structured methodological approach.
• The file is shared under a permissive CC-BY-4.0 license, allowing for reuse and redistribution.

Limitations

• The core data is embedded within a 12.8 MB PDF, requiring extraction and may not be in a readily machine-readable format.
• Column-level documentation and sample data are unavailable, making field semantics and structure difficult to assess prior to download.
• Row count and the exact scope of the supplementary data (e.g., full tables vs. selected figures) are unknown.

Provenance

Source

figshare, uploaded by author Jing Bai.

Collection Method

Likely contains processed results from bulk RNA-seq analysis and in vitro cell culture experiments, as described.

Freshness

Last updated 2026-04-30 04:18:13; freshness should be verified.