Murine Hepatic Immune Cell Profiles During Aging from CyTOF Analysis

A single-cell mass cytometry (CyTOF) dataset profiling immune cell subsets in mouse livers during aging. The data, authored by Zheng Ding and last updated in April 2026, is shared under a CC-BY-4.0 license as a 1.8 MB ZIP file. It reveals age-associated alterations in B cell, T cell, and macrophage populations.

Use Cases

• Identify age-related shifts in immune cell populations based on the described profiling of B, T, and macrophage subsets.
• Analyze pathway enrichment in specific cell types based on the mention of altered B cell signal transduction pathways.
• Characterize pro-inflammatory macrophage states in aged tissue based on the reported increase in resident-derived M1 macrophages.
• Model the dynamics of CD4+ T cell subset expansion (Th1, Th2, Th17, Treg) during aging as described in the results.

Strengths

• Data is shared under a permissive CC-BY-4.0 license, facilitating reuse and distribution.
• The description provides specific biological findings, such as the reduction of Igd+ B cells and expansion of specific CD4+ T cell subsets.
• File size is 1.8 MB, indicating a relatively compact and manageable download.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• The dataset is focused on a murine model, which may limit direct applicability to human aging studies.
• Description metadata is limited; actual data structure and quality require manual inspection after download.

Provenance

Source

figshare

Collection Method

Single-cell mass cytometry (CyTOF) profiling of murine liver tissue.

Time Range

Not specified in the provided metadata.

Freshness

Last updated 2026-04-28 04:25:15

Geography

Not specified in the provided metadata.