Mouse Dentate Gyrus Gene Expression After Entorhinal Denervation, 1-28 Days

Supplementary file 2_Spatiotemporal patterns of gene expression changes in the mouse dentate gyrus following entorhinal denervation.xlsx contains transcriptomic data from a mouse brain injury study. The dataset, authored by Jessica Schlaudraff and shared under CC-BY-4.0, includes whole-genome expression analysis from laser-microdissected tissue samples. Data was collected at 1, 3, 7, 14, and 28 days post-lesion from the outer molecular layer and granule cell layer.

Use Cases

• Modeling temporal gene expression dynamics based on the 1-28 day post-lesion time series
• Analyzing layer-specific (OML vs. GCL) transcriptomic responses to denervation mentioned in the description
• Investigating pathways related to reactive gliosis, synaptic reorganization, and metabolic adaptation highlighted in the results
• Identifying co-expression patterns of specific gene families (e.g., glutamate receptors, synaptic adhesion mediators) listed in the dataset

Strengths

• Data includes specific quantitative results, such as Sema3e reduced to 60% in OML and Nrp1 induced 3-fold in OML and 7-fold in GCL.
• Temporal resolution is defined with samples at 1, 3, 7, 14, and 28 days post-lesion.
• Spatial resolution is provided with tissue isolated from two distinct brain layers (OML and GCL).
• Dataset is 6.2 MB in size, suggesting a focused and manageable data volume.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain analyses.
• Description metadata is limited; actual data quality and completeness require manual inspection after download.

Provenance

Source

Jessica Schlaudraff via figshare

Collection Method

Whole-genome expression analysis on laser-microdissected tissue from mouse dentate gyrus after perforant path transection.

Time Range

Samples collected at 1, 3, 7, 14, and 28 days post-lesion.

Freshness

Last updated 2026-05-19 05:40:45; freshness should be verified.