Studies on the Anticonvulsant Potential of 6-Gingerol in Zebrafish and Mice

Supplementary file 2 contains research data on the anticonvulsant effects of 6-gingerol, an active compound from ginger. The study, authored by Dorota Nieoczym and last updated on 2026-04-23, investigates the compound's effects using multiple seizure models in zebrafish larvae and mice. The dataset is a 16.5 KB DOCX file shared under a CC-BY-4.0 license on figshare.

Use Cases

• Evaluating the efficacy of 6-gingerol as an anticonvulsant based on results from the pentylenetetrazole (PTZ) and ethyl 2-ketopent-4-enoate seizure tests in zebrafish.
• Investigating the blood-brain barrier penetration of natural compounds based on the described mouse model using 6 Hz electrical stimulation.
• Analyzing gene expression changes (npas4, bdnf) in seizure models following treatment with 6-gingerol.
• Comparing the effects of a compound across different seizure and epilepsy models, including the pilocarpine model and scn1lab and cacna1aa zebrafish morphants.

Strengths

• Dataset is openly licensed (CC-BY-4.0), allowing for reuse and redistribution.
• The description provides specific details on experimental models and outcomes, such as the 6 Hz electrical stimulation at 32 mA and 44 mA intensities.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• The dataset is very small (16.5 KB), suggesting limited scope, likely a supplementary document rather than a primary data table.
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

figshare

Collection Method

Likely contains experimental data from pharmacological studies on zebrafish and mice.

Freshness

Last updated 2026-04-23 05:34:51; freshness should be verified.