Transcriptomic Profiles of Antioxidant Treatments in Human Skin Cells

A collection of 197 differentially expressed genes (DEGs) identified from RNA sequencing of human epidermal keratinocytes, melanocytes, and fibroblasts treated with chlorogenic acid, taurine, or their combination. It prioritizes 62 aging-related DEGs (AR-DEGs) linked to skin aging and anti-senescence pathways. The data was generated by Beomsu Kim and published on figshare in March 2026.

Use Cases

• Analyze the 197 differentially expressed genes (DEGs) to identify common regulatory patterns across keratinocytes, melanocytes, and fibroblast cell types.
• Investigate the 62 prioritized aging-related DEGs (AR-DEGs), such as FST, for associations with skin aging phenotypes like perceived age and pigmentation.
• Examine gene expression changes following co-treatment to identify synergistic responses between chlorogenic acid and taurine.
• Validate key regulatory transcription factors like TGFB2, ETS1, and EGR1 identified in anti-senescence-associated pathways using the transcriptomic data.

Strengths

• Focuses on 197 differentially expressed genes (DEGs) specifically related to antioxidant treatments in skin cells.
• Prioritizes 62 aging-related DEGs (AR-DEGs) based on integration of evidence from aging databases, GWAS, and pathway annotations.
• Data is recent, last updated in March 2026.

Limitations

• The dataset is small at 1.9 MB, suggesting limited scope or aggregated summary data rather than raw sequencing reads.
• Specific sample size (rows) and column structure are unknown, limiting detailed reproducibility and analysis.
• Findings are derived from in vitro cell culture models (keratinocytes, melanocytes, fibroblasts), which may not fully reflect in vivo skin biology.

Provenance

Source

figshare, author Beomsu Kim.

Collection Method

Transcriptome-wide RNA sequencing of treated human skin cells, integrated with evidence from aging databases, GWAS, and pathway analysis.

Freshness

Last updated 2026-03-20.