CEBPD Expression Data: A Molecular Indicator for Fibrosis in Uterine Leiomyoma

CEBPD gene expression data from two independent uterine leiomyoma cohorts (GSE64763, GSE95101) shows significant downregulation in fibrotic tissues. The dataset includes results from single-cell RNA sequencing analysis mapping CEBPD's cellular distribution and its correlation with epithelial-mesenchymal transition factors. Ran Duan published this supplementary file on figshare in May 2026 under a CC-BY-4.0 license.

Use Cases

• Evaluate diagnostic biomarker performance based on receiver operating characteristic curve analysis results
• Analyze gene expression correlations with fibrotic mediators like COL1A1, COL1A2, and COL3A1
• Investigate cellular distribution patterns within the tumor microenvironment using single-cell RNA sequencing data
• Study the relationship between CEBPD expression and epithelial-mesenchymal transition progression

Strengths

• Diagnostic performance validated in two independent cohorts with AUC values of 0.878 and 0.858
• Analysis includes single-cell RNA sequencing data identifying 8 cell subsets in the tumor microenvironment
• Histological validation performed using H&E and double immunofluorescence staining on clinical specimens

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The 151.9 KB file size suggests a limited scope of data

Provenance

Source

figshare

Collection Method

Transcriptional profile analysis of uterine leiomyoma cohorts and single-cell RNA sequencing

Freshness

Last updated 2026-05-19 05:38:34; freshness should be verified