Multi-Omics Analysis of MARCKS and GSDMD Pathway Genes in Tuberculous Meningitis

Supplementary file 3 from a multi-omics analysis of blood-brain barrier disruption in tuberculous meningitis (TBM). The dataset, authored by Mengyu Luan and shared on figshare under CC-BY-4.0, contains results identifying upregulated genes like MARCKS, CD274, and IL17RA. It was last updated on 2026-06-03.

Use Cases

• Validate gene co-expression patterns based on the identified association between MARCKS and GSDMD pathway effectors.
• Perform functional enrichment analysis based on the described nexus of inflammatory signaling and cytoskeletal regulation.
• Cross-reference single-cell expression data based on the finding of predominant MARCKS expression in CNS microglia.
• Investigate potential therapeutic targets based on the nomination of MARCKS as a mechanistic hub for barrier-stabilizing strategies.

Strengths

• Dataset is openly licensed under CC-BY-4.0.
• Analysis integrates multiple data sources, including bulk and single-cell RNA sequencing from clinical and murine datasets.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 17.0 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Integrated multi-omics approach combining bulk and single-cell RNA sequencing with experimental validation.

Freshness

Last updated 2026-06-03 05:43:03; freshness should be verified.