Network Meta-Analysis of Vitamin D Combination Therapies for Pediatric Rickets

Ten randomized controlled trials involving 867 children compare nine vitamin D-based combination regimens against monotherapy. The analysis, conducted by Yunfeng Cao, was published in 2026 and evaluates efficacy and safety through indirect comparisons of biochemical markers.

Use Cases

• Rank relative efficacy of different vitamin D combinations on serum 25-hydroxyvitamin D levels using network meta-analysis results.
• Compare safety profiles of nine regimens by analyzing adverse event rates reported across the included trials.
• Assess treatment effect differences between term and preterm infant subgroups based on the reported subgroup analysis (P < 0.001).
• Evaluate the impact of combination therapies on bone-specific alkaline phosphatase, serum calcium, and phosphate concentrations from the pairwise meta-analyses.

Strengths

• Analysis synthesizes data from 10 randomized controlled trials.
• Includes 867 pediatric patients across the pooled studies.
• Findings were validated via sensitivity analyses confirming robustness.

Limitations

• Limited to 867 total patients, a small sample for subgroup inferences.
• Evidence base is constrained to 10 trials, indicating a need for more high-quality studies.
• The 694.0 KB file contains only the analysis manuscript, not the underlying trial-level data.

Provenance

Source

Systematic review and network meta-analysis published on figshare.

Collection Method

Bayesian network meta-analysis of RCTs sourced from PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang, and VIP databases.

Time Range

null

Freshness

Last updated in April 2026.

Geography

null