Supplementary file 3_Exercise-induced changes in systemic inflammatory biomarkers in overw

Lei Chen's supplementary file from a 2026 study integrates bibliometric analysis and an umbrella review of meta-analyses. The work maps global research trends from 2005 to 2025 and evaluates evidence certainty for exercise's effect on biomarkers like CRP, IL-1β, and IL-8 in overweight and obese populations. The dataset is a 551.2 KB PDF containing the analysis results and supporting information.

Use Cases

• Reviewing evidence certainty for exercise's effect on specific inflammatory biomarkers based on the GRADE framework results.
• Analyzing publication trends and knowledge structure in exercise immunology research based on the bibliometric analysis of 12,101 records.
• Assessing methodological quality and overlap in systematic reviews based on the application of AMSTAR-2, ROBIS, and CCA tools.
• Comparing pooled effect sizes for different biomarkers like CRP, IL-6, and TNF-α based on the re-estimated standardized mean differences.

Strengths

• The underlying umbrella review synthesizes evidence from 25 meta-analyses encompassing 342 randomized controlled trials and over 30,000 participants.
• The bibliometric analysis provides a structured overview of 12,101 research records from 2005 to 2025.
• Evidence is appraised using established frameworks including GRADE, AMSTAR-2, and ROBIS.

Limitations

• The dataset is a single 551.2 KB PDF document; the underlying raw data or column-level details are not provided.
• Row count and specific data structure are unknown, which may limit suitability assessment for computational analysis.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Lei Chen, published on figshare.

Collection Method

Generated from a study combining bibliometric analysis of Web of Science records with an umbrella review of meta-analyses of RCTs.

Time Range

Bibliometric data covers 2005 to 2025; meta-analyses were searched through December 1, 2025.

Freshness

Last updated 2026-05-20 05:47:54.