Integrative circRNA Landscape of Intrauterine Adhesions: ceRNA Axes and Splicing Usage

1,724 high-confidence circRNAs from 1,143 host genes were identified in a reanalysis of RNA sequencing data from intrauterine adhesions and controls. The dataset includes differential expression analysis, ceRNA circuit construction, and splicing usage quantification linked to uterine contractility and immunity. Yingqing Chen published this integrative circRNA map on figshare in May 2026.

Use Cases

• Identify dysregulated circRNA biomarkers for intrauterine adhesions based on differential expression analysis.
• Construct competing endogenous RNA (ceRNA) circuits linking circRNAs to smooth muscle contractility genes.
• Analyze circRNA-associated splicing usage shifts in pathways related to fibrotic remodeling.
• Correlate circRNA expression with macrophage phenotypes using immune deconvolution results.
• Explore co-expression networks between splicing events and RNA-binding proteins like EXO1 and SORBS1.

Strengths

• Includes 1,724 high-confidence circRNAs identified using four independent callers.
• Integrates multiple analyses: differential expression, ceRNA circuits, splicing usage, and immune deconvolution.
• Validation was performed in an independent clinical cohort using RT-qPCR and Western blotting.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small, at 529.3 KB, indicating limited scope.

Provenance

Source

Reanalysis of rRNA-depleted RNA sequencing data from GSE224093.

Collection Method

CircRNA assembly using four independent callers, differential expression analysis, ceRNA circuit construction, and splicing usage quantification.

Freshness

Last updated 2026-05-07 04:37:43; freshness should be verified.