Long-Term Effects of Ceftiofur and Ampicillin on Resistant Bacteria in Dairy Cow Feces

A dataset from a randomized clinical trial on 24 healthy lactating Holstein cows. It compares the long-term fecal shedding of antibiotic-resistant Gram-negative bacteria after systemic treatment with ceftiofur or ampicillin versus a control group over a 12-week period. The data was published by Juliano L. Gonçalves under a CC-BY-4.0 license and last updated in April 2026.

Use Cases

• Modeling the duration of resistant bacteria shedding based on weekly fecal sampling over 11 weeks.
• Comparing the abundance of resistant Gram-negative bacteria across different antibiotic treatment groups.
• Analyzing the proportion of resistant bacteria relative to total bacterial counts mentioned in the methodology.
• Investigating the relative abundance of antimicrobial resistance gene classes, such as beta-lactams, from preliminary molecular results.

Strengths

• Data originates from a controlled, randomized clinical trial with 8 cows per treatment group.
• Includes longitudinal measurements from weekly fecal samples collected over an 11-week period.
• Released under a permissive CC-BY-4.0 license, allowing for reuse and redistribution.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The dataset is very small at 83.0 KB, indicating limited scope and likely summary-level results.
• Description metadata is limited; actual data quality and granularity require verification.

Provenance

Source

figshare

Collection Method

Randomized clinical trial with fecal grab samples, spiral plating on selective agar, and generalized linear mixed models.

Time Range

Clinical trial period of 12 weeks.

Freshness

Last updated 2026-04 30 14:30:38; freshness should be verified.

Geography

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