Poge Heart-Saving Decoction Metabolites and Mouse Heart Failure Experiment Data

133 metabolites were identified in the Poge Heart-Saving Decoction (PHSD) formula. Experimental data includes cardiac function parameters, NT-proBNP levels, and histopathological, protein, and mRNA expression analyses from a mouse heart failure model treated with low, medium, or high doses of PHSD. The dataset supports investigation into the therapeutic mechanisms of PHSD targeting the PI3K/AKT pathway.

Use Cases

• Analyze the relationship between identified metabolites and protein expression levels of AKT1, TNF, and BCL-2 from network analysis.
• Correlate cardiac function parameters from echocardiography with histopathological findings of myocardial apoptosis and fibrosis.
• Compare the expression levels of Collagen I, Collagen III, PI3K, and AKT across different PHSD treatment doses in the mouse model.
• Examine the dose-response relationship between PHSD treatment and NT-proBNP levels as a biomarker for heart failure severity.

Strengths

• Contains data on 133 identified metabolites from the PHSD formula.
• Includes multi-modal experimental data: echocardiography, biomarker levels (NT-proBNP), histopathology, and molecular expression analysis.
• Experiments were conducted with three distinct treatment doses (low, medium, high) for comparative analysis.

Limitations

• The dataset is derived from a single animal model study (mouse), limiting direct generalizability to human physiology.
• Specific sample sizes (e.g., number of mice per group) and the total number of data rows are not provided.
• Data is focused on a specific mechanistic pathway (PI3K/AKT), which may not capture all biological effects of the treatment.

Provenance

Source

figshare, authored by Lei Du.

Collection Method

Data generated from UHPLC-MS/MS metabolite characterization and in vivo experiments on an isoproterenol-induced mouse heart failure model.

Freshness

Last updated in March 2026.