Preclinical Meta-Analysis of Moringa Oleifera for Peptic Ulcer Disease

Featuring the supplementary data from a systematic review and meta-analysis of 11 preclinical studies involving 268 animals. It evaluates the therapeutic efficacy of Moringa oleifera extracts on ulcer index in rodent models of peptic ulcer disease. The analysis includes pooled effect sizes, subgroup analyses by dose and comparator, and assessments of heterogeneity and publication bias.

Use Cases

• Perform subgroup meta-analysis on ulcer index data segmented by dose (e.g., high-dose) and comparator (e.g., standard drugs vs. basal controls)
• Assess heterogeneity (I² statistic) and publication bias (Egger’s regression) across the 11 included preclinical studies
• Replicate sensitivity analyses using the provided data to verify the resolved heterogeneity (I² = 0%) and overall outcomes

Strengths

• Data is derived from a systematic review of 11 studies with defined inclusion criteria and a SYRCLE quality score range of 8 to 9
• Meta-analysis includes pooled effect size (SMD = -1.42) for ulcer index from 268 animal subjects
• Dataset is structured for reproducibility, containing subgroup and sensitivity analyses as described in the published review

Limitations

• Limited to 11 preclinical studies, representing a small evidence base for meta-analysis
• Data is exclusively from rodent models, limiting direct translational relevance to human clinical outcomes
• High heterogeneity (I² = 69%) was noted in some subgroup analyses, indicating methodological variability

Provenance

Source

figshare, authored by Saheed Olatunbosun Akiode

Collection Method

Systematic review and meta-analysis of eligible studies from PubMed, CINAHL, Scopus, Web of Science, and Cochrane Library up to August 2025

Time Range

Studies from database inception to August 2025

Freshness

Last updated 2026-03-20.