SHP2 in TAMs: Gene and Protein Expression Data for Gastric Adenocarcinoma Survival Study

A figshare dataset by Jing Bai, last updated April 30, 2026, containing supplementary data from a study on tumor-associated macrophages in gastric cancer. The 15.5 KB Excel file likely holds results from bulk RNA-seq analysis of the GSE118916 dataset and protein expression measurements from cell culture experiments. The study investigated the role of SHP2 in macrophage polarization and its effect on cancer cell death, migration, and invasion.

Use Cases

• Analyze differential gene expression patterns in gastric cancer based on bulk RNA-seq results mentioned in the description.
• Investigate correlations between immune cell infiltration and gene expression based on the immune infiltration analysis described.
• Study the effects of SHP2, SP1, and BRD4 modulation on protein expression levels of p-P38, p-ERK1/2, and inflammation-related cytokines.
• Examine relationships between molecular pathways (P38/ERK1/2/SP1/BRD4/STING) and M2 macrophage polarization markers like Arg-1 and Cathepsin K.

Strengths

• Dataset is openly licensed under CC-BY-4.0, permitting reuse and redistribution.
• File size is 15.5 KB, indicating a focused and potentially manageable dataset for analysis.
• Description details specific experimental methods including bulk RNA-seq, cell co-culture, and inhibitor treatments.

Limitations

• Row count and column definitions are unknown, limiting suitability assessment for specific analyses.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect bias inherent to the specific cell lines (THP-1, AGS) and experimental conditions used.

Provenance

Source

figshare, author Jing Bai.

Collection Method

Data likely generated from laboratory experiments including bulk RNA-seq analysis of the GSE118916 dataset and in vitro cell culture with SHP2 modulation.

Freshness

Last updated 2026-04-30 04:18:13; freshness should be verified.