Network Meta-Analysis of Vitamin D Combination Therapies for Pediatric Rickets

Yunfeng Cao's supplementary document provides a systematic review and Bayesian network meta-analysis comparing nine vitamin D-based combination regimens for nutritional rickets. The analysis synthesizes data from 10 randomized controlled trials involving 867 children. The document was uploaded to figshare in April 2026.

Use Cases

• Compare relative efficacy rankings of nine vitamin D combination regimens based on serum 25-hydroxyvitamin D levels.
• Assess safety profiles of different combination therapies using adverse event data from included trials.
• Analyze outcome-specific advantages of regimens using network meta-analysis results for bone-specific alkaline phosphatase, serum calcium, and phosphate.
• Evaluate subgroup differences in treatment response between term and preterm infants using reported P-values.

Strengths

• Analysis includes 10 randomized controlled trials with a total of 867 pediatric patients.
• Systematic review protocol was prospectively registered in PROSPERO (CRD420251029274).
• Compares nine distinct vitamin D-based combination regimens against monotherapy.

Limitations

• Limited patient pool of 867 children may reduce statistical power for some subgroup analyses.
• Data scope is confined to the specific biochemical markers and safety outcomes reported in the 10 included trials.
• The 527.7 KB document is a summary analysis, not a raw clinical trial dataset.

Provenance

Source

Yunfeng Cao, uploaded to figshare.

Collection Method

Bayesian network meta-analysis of data systematically retrieved from PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang, and VIP databases.

Time Range

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Freshness

Document uploaded April 2026, based on a PROSPERO registration from 2025.

Geography

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