Supplementary file 4_Effect of acupuncture on monoaminergic neurotransmitters in animal mo

Lixiang Gan uploaded a supplementary document on 2026-05-11 summarizing a preclinical systematic review and meta-analysis. The 15.7 KB DOCX file contains results from nine studies involving 386 rodents, analyzing the effect of acupuncture on monoaminergic neurotransmitters in animal models of vascular dementia. The meta-analysis calculated standardized mean differences for serotonin, norepinephrine, dopamine, acetylcholine, long-term potentiation, and behavioral outcomes.

Use Cases

• Reviewing meta-analysis methodology based on the described PRISMA 2020 guidelines and SYRCLE risk-of-bias assessment.
• Analyzing effect sizes for neurotransmitter modulation based on the reported standardized mean differences for 5-HT, NE, DA, and ACh.
• Assessing cognitive improvement metrics based on the described Morris water maze test results for escape latency and platform crossings.

Strengths

• The dataset is associated with a registered systematic review (PROSPERO CRD420251179267).
• Meta-analysis results include specific standardized mean difference values for six distinct outcome measures.
• The underlying research synthesized data from eight databases and followed PRISMA 2020 guidelines.

Limitations

• The dataset is a 15.7 KB DOCX summary file; the underlying raw data from the nine included studies is not provided.
• Column-level documentation is absent; field semantics must be inferred from the textual description.
• The authors note substantial heterogeneity and small sample sizes in the included studies, limiting generalizability.

Provenance

Source

Lixiang Gan via figshare.

Collection Method

Systematic review and meta-analysis of randomized controlled animal studies.

Time Range

Literature search conducted from database inception to October 2025.

Freshness

Last updated 2026-05-11 04:24:42; freshness should be verified.