Supplementary file 4_Exercise-induced changes in systemic inflammatory biomarkers in overw

A 2025 umbrella review and bibliometric analysis of research from 2005 to 2025 on exercise and inflammation. The dataset is a supplementary PDF file containing results from 25 meta-analyses encompassing 342 randomized controlled trials with over 30,000 participants. It was authored by Lei Chen and shared under a CC-BY-4.0 license on figshare.

Use Cases

• Evaluating the certainty of evidence for exercise reducing C-reactive protein (CRP) based on pooled standardized mean differences.
• Mapping global research trends in exercise immunology for overweight populations based on bibliometric analysis of 12,101 records.
• Assessing heterogeneity and publication bias in evidence for interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) based on the GRADE framework classifications.
• Identifying research gaps for biomarkers like interleukin-10 (IL-10) based on reported non-significant systemic responses.

Strengths

• Aggregates evidence from 342 randomized controlled trials involving over 30,000 participants.
• Applies multiple quality assessment frameworks including AMSTAR-2, ROBIS, and GRADE.
• Bibliometric analysis covers a 20-year span (2005-2025) with 12,101 records.
• Reports specific effect sizes (standardized mean differences) with confidence intervals for multiple biomarkers.

Limitations

• The dataset is a single 761.1 KB PDF file; underlying raw data or column definitions are not provided.
• Row count and data structure are unknown, limiting suitability assessment for computational analysis.
• Freshness should be verified as the last update was 2026-05-20, which is a future date relative to the input.

Provenance

Source

figshare, author Lei Chen

Collection Method

Bibliometric analysis and umbrella review of meta-analyses from databases including Web of Science Core Collection.

Time Range

Bibliometric data from 2005 to 2025; meta-analyses searched through December 1, 2025.

Freshness

Last updated 2026-05-20 05:47:55