CircRNA Landscape of Intrauterine Adhesions: CeRNA Axes and Splicing Usage

A 2026 study by Yingqing Chen provides a catalog of 1,724 high-confidence circular RNAs from 1,143 host genes, derived from reanalyzed RNA sequencing data. It integrates ceRNA circuits and splicing usage profiles to link circRNAs to uterine contractility, cell-cycle control, and immune activation in intrauterine adhesions.

Use Cases

• Identifying dysregulated circRNA biomarkers for intrauterine adhesions based on the catalog of 1,724 high-confidence circRNAs.
• Constructing competing endogenous RNA (ceRNA) networks linking circRNAs to smooth muscle contractility and cell-cycle genes.
• Analyzing circRNA-associated splicing usage shifts in pathways related to uterine contractility and EGFR signaling.
• Investigating correlations between circRNA expression and macrophage phenotypes (M1/M2) in fibrotic tissue.

Strengths

• Catalog includes 1,724 high-confidence circRNAs derived from four independent circRNA callers.
• Analysis integrates multiple approaches: ceRNA circuits, splicing usage profiling, and immune deconvolution.
• Results were validated in an independent clinical cohort using RT-qPCR and Western blotting.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is a single PDF file (137.5 KB), suggesting it contains summary results rather than raw data tables.

Provenance

Source

figshare

Collection Method

Reanalysis of rRNA-depleted RNA sequencing data from GSE224093.

Freshness

Last updated 2026-05-07 04:37:44