Fecal Shedding of Resistant Bacteria in Dairy Cows After Systemic Antibiotic Treatment

24 healthy lactating Holstein cows were randomly assigned to receive ceftiofur, ampicillin, or a control treatment over 5 days in a randomized clinical trial. Fecal samples were collected weekly for 11 weeks to measure the abundance of resistant Gram-negative bacteria, with results indicating minimal long-term changes. The dataset, authored by Juliano L. Gonçalves and licensed CC-BY-4.0, was last updated on 2026-04-30.

Use Cases

• Analyzing the longitudinal effects of systemic antibiotic treatments on fecal bacterial resistance based on weekly sampling over 11 weeks.
• Comparing the abundance of Gram-negative bacteria resistant to specific antibiotics (ampicillin, ceftiofur) between treatment and control groups.
• Modeling the duration of resistant bacteria shedding in feces following a clinical trial intervention.
• Investigating the relative abundance of antimicrobial resistance gene classes (e.g., MLS, aminoglycoside) mentioned in the molecular results.

Strengths

• Data originates from a controlled randomized clinical trial with 8 cows per treatment group.
• Sampling protocol is detailed, with weekly fecal collections spanning 11 weeks post-treatment.
• License is permissive (CC-BY-4.0), facilitating reuse and analysis.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The dataset is very small (16.8 KB), indicating limited scope or summary-level data.
• Description metadata is limited; actual data quality and granularity require verification.

Provenance

Source

figshare

Collection Method

Randomized clinical trial with fecal samples collected, diluted, and inoculated on selective agar for bacterial enumeration.

Time Range

Clinical trial period spanned at least 12 weeks, including treatment and weekly sampling.

Freshness

Last updated 2026-04-30 14:30:38; freshness should be verified.

Geography

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