Poge Heart-Saving Decoction Metabolite and Mouse Heart Failure Experiment Data

133 metabolites were identified in the Poge Heart-Saving Decoction (PHSD) formulation. Experimental data includes cardiac function parameters, NT-proBNP levels, and protein/mRNA expression levels for apoptosis and fibrosis markers from a mouse heart failure model treated with low, medium, or high doses of PHSD. The dataset supports analysis of the PI3K/AKT pathway's role in heart failure treatment.

Use Cases

• Analyze the relationship between PHSD dose levels and cardiac function parameters (e.g., from echocardiography) to model treatment efficacy.
• Correlate protein expression levels of BAX, BCL-2, PI3K, and AKT with histopathological findings on myocardial apoptosis and fibrosis.
• Investigate the association between NT-proBNP levels and collagen deposition (Collagen I, Collagen III) across different treatment groups.

Strengths

• Contains data on 133 identified metabolites from the PHSD formulation.
• Includes multi-modal experimental measurements: cardiac function, histopathology, and molecular expression levels.
• Data is structured in an XLSX file, facilitating tabular analysis.

Limitations

• The dataset is small in file size (417.9 KB), indicating limited scope and likely a low number of experimental subjects or observations.
• Data is derived from a single animal model study, limiting generalizability to human clinical contexts.
• Specific row and column counts are unknown, making it difficult to assess the dataset's analytical scale upfront.

Provenance

Source

Author Lei Du, published on figshare.

Collection Method

Data generated from in vivo mouse experiments involving isoproterenol-induced heart failure, treated with PHSD, with subsequent echocardiography, histopathology, and molecular analyses.

Freshness

Last updated on 2026-03-25.