COVID-19 Vaccine Adverse Event Profiles from VAERS 2020-2024

2020-2024 VAERS data provides an updated analysis of adverse events for Pfizer-BioNTech, Moderna, Janssen, bivalent, and Novavax vaccines. The study includes age- and sex-stratified analyses and uses Ontology of Adverse Events classification to categorize significant events.

Use Cases

• Compare AE profiles across vaccine types like Pfizer-BioNTech, Moderna, Janssen, bivalent, and Novavax to identify distinct safety patterns.
• Conduct age-stratified analysis to examine bimodal reporting patterns in children aged 0–9 and adults aged 50–69.
• Perform sex-stratified analysis to compare AE frequencies, such as sensory-related events in females versus cardiovascular-related events in males.
• Analyze specific serious AEs like thrombosis, myocarditis, and Guillain-Barré syndrome across different vaccine formulations.
• Use Ontology of Adverse Events classification to structure and interpret significant adverse event data within a hierarchical framework.

Strengths

• Analysis spans data through 28 June 2024, providing updated temporal coverage.
• Includes multiple vaccine types: monovalent, bivalent mRNA, recombinant vector, and protein subunit vaccines.
• Employs statistical methods like Pearson’s Chi-square test and proportional reporting ratios for significance determination.

Limitations

• Dataset is a 23.3 KB supplementary file, indicating a summary or processed results table, not the raw VAERS data.
• Underlying row and column counts are unknown, limiting assessment of analytical scope.
• Findings are based on processed VAERS data via Cov19VaxKB, not direct from the original source system.

Provenance

Source

Processed Vaccine Adverse Event Reporting System (VAERS) data obtained via Cov19VaxKB.

Collection Method

Systematic analysis of AE profiles using statistical tests and Ontology of Adverse Events classification.

Time Range

2020–2024, with data through 28 June 2024.

Freshness

Data analyzed through 28 June 2024; file last updated 2026-03 26.

Geography

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