Fine-Wool Sheep Skin Single-Cell RNA-Seq Atlas for Fiber Diameter Analysis

A single-cell RNA sequencing atlas of skin tissues from six half-sibling fine-wool sheep reared under identical conditions but exhibiting different fiber diameters. The dataset contains 59,732 high-quality cells systematically annotated into 14 distinct cell types, including dermal papilla cells, hair follicle stem cells, and outer root sheath cells. It was created by Tong Xiao and last updated on June 1, 2026.

Use Cases

• Identify cell type-specific gene expression profiles based on the 14 annotated cell types.
• Analyze cell proportion differences between wool fiber diameter groups (ultra-fine, medium-fine, fine).
• Investigate cell-cell communication networks based on the ligand-receptor pairs identified.
• Reconstruct developmental trajectories of epidermal lineage cells using pseudotime analysis.
• Validate molecular mechanisms of fiber diameter by studying differentially expressed genes like CRABP1.

Strengths

• 59,732 high-quality single cells captured, providing a substantial cellular snapshot.
• 14 distinct cell types annotated using known marker genes, offering clear biological context.
• Comparative analysis across three experimental groups (ultra-fine, medium-fine, fine wool) is included.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is from a specific cohort of six half-sibling sheep, limiting generalizability.

Provenance

Source

figshare

Collection Method

Single-cell RNA sequencing performed on skin tissues from six half-sibling fine-wool sheep.

Freshness

Last updated 2026-06-01 05:25:34; freshness should be verified.