Poge Heart-Saving Decoction Effects on Heart Failure in Mice

Lei Du's research article details a study on the traditional Chinese medicine Poge Heart-Saving Decoction (PHSD) and its effects on heart failure. The study identifies 133 metabolites in PHSD and uses a mouse model to analyze cardiac function, apoptosis, and fibrosis. Results indicate PHSD ameliorates heart failure by suppressing apoptosis and fibrosis via the PI3K/AKT pathway.

Use Cases

• Analyze the 133 identified PHSD metabolites for network pharmacology studies on heart failure mechanisms.
• Study the relationship between protein expression levels of BAX, BCL-2, PI3K, and AKT in myocardial tissue under PHSD treatment.
• Examine histopathological data on Collagen I and Collagen III deposition to assess fibrosis reduction in ISO-induced mouse models.
• Correlate echocardiography cardiac function parameters with NT-proBNP levels to evaluate therapeutic efficacy of PHSD doses.

Strengths

• Identifies 133 specific metabolites within the PHSD formulation for mechanistic analysis.
• Provides in vivo experimental data from a controlled mouse model of isoproterenol-induced heart failure.
• Includes multi-modal data: metabolite characterization, network analysis, echocardiography, histopathology, and protein/mRNA expression.

Limitations

• Dataset is a single 3.4 MB PDF file; underlying raw tabular or image data are not directly accessible.
• Sample size and specific row/column counts for experimental measurements are not provided in the description.
• Findings are specific to a mouse model, limiting direct extrapolation to human clinical contexts.

Provenance

Source

Lei Du via figshare.

Collection Method

Experimental study using UHPLC-MS/MS metabolite characterization, network analysis, and in vivo mouse model with echocardiography, histopathology, and molecular assays.

Freshness

Last updated March 25, 2026.