COVID-19 Vaccine Adverse Event Profiles 2020-2024

2020-2024 analysis profiles adverse events for Pfizer-BioNTech, Moderna, Janssen, bivalent, and Novavax vaccines using VAERS data. The study identifies significant differences in thrombosis, myocarditis, and Guillain-Barré syndrome across vaccine types and reveals age- and sex-specific reporting patterns. It employs Ontology of Adverse Events classification for structured interpretation.

Use Cases

• Compare AE profiles for monovalent versus bivalent Pfizer-BioNTech and Moderna vaccines using reported frequencies and proportional reporting ratios.
• Analyze sex differences in AE reporting, where females report more sensory-related events and males report more cardiovascular-related events like myocarditis.
• Investigate age-stratified patterns, such as higher AE reporting in children aged 0–9 and adults aged 50–69.
• Assess the significance of specific serious AEs, including thrombosis and Guillain-Barré syndrome, across different vaccine types.
• Utilize Ontology of Adverse Events classification to categorize and hierarchically interpret significant adverse event patterns.

Strengths

• Analysis covers data through 28 June 2024, providing updated safety trends.
• Includes multiple vaccine types: Pfizer-BioNTech, Moderna, Janssen, bivalent formulations, and Novavax.
• Employs statistical methods like Pearson’s Chi-square test and proportional reporting ratios for significance determination.
• Structured interpretation via Ontology of Adverse Events classification.

Limitations

• Dataset scope is limited to 28.2 KB, indicating a summary or processed results file, not the raw VAERS case reports.
• Unknown row and column counts prevent assessment of data volume and feature granularity.
• Relies on processed VAERS data via Cov19VaxKB, which may involve aggregation or filtering not detailed in the input.

Provenance

Source

Vaccine Adverse Event Reporting System (VAERS), processed via Cov19VaxKB.

Collection Method

Systematic analysis of AE profiles using statistical tests and ontology-based classification.

Time Range

2020-2024, with data through 28 June 2024.

Freshness

Last updated 2026-03-26.

Geography

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