Network Meta-Analysis of Vitamin D Combination Therapies for Pediatric Rickets

A 2026 network meta-analysis by Yunfeng Cao synthesizes evidence from 10 randomized controlled trials involving 867 children. The study compares the efficacy and safety of nine vitamin D-based combination regimens against vitamin D3 monotherapy for treating nutritional rickets. It was registered in PROSPERO and published on figshare.

Use Cases

• Compare relative efficacy rankings of nine vitamin D combination regimens on outcomes like serum 25-hydroxyvitamin D levels.
• Assess safety profiles of different combination therapies using adverse event data from the included trials.
• Analyze subgroup differences, such as treatment effect variations between term and preterm infants.
• Validate network meta-analysis findings using the reported sensitivity analysis results.

Strengths

• Evidence synthesized from 10 randomized controlled trials.
• Analysis includes data from 867 pediatric patients.

Limitations

• Limited scope with only 10 trials and 867 total participants.
• Underlying trial data is not provided, only the analysis summary.
• Geographic and demographic specifics of the patient population are not detailed.

Provenance

Source

figshare, author Yunfeng Cao.

Collection Method

Systematic review and Bayesian network meta-analysis of trials from PubMed, Embase, Cochrane Library, and Chinese databases.

Time Range

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Freshness

Last updated in April 2026.

Geography

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