Expert Recommendations for Airway Pressure Release Ventilation Settings

Gary F. Nieman's 2026 publication provides expert consensus guidance on setting and adjusting Airway Pressure Release Ventilation (APRV) for adult patients with ARDS. The document synthesizes clinical experience and basic science evidence into a protocol for the four APRV parameters: P_High, T_High, P_Low, and T_Low.

Use Cases

• Extract structured recommendations for P_High, T_High, P_Low, and T_Low settings to inform clinical decision support systems.
• Analyze the consensus protocol for titrating APRV settings in response to changes in lung physiology.
• Identify injurious APRV settings, such as those impairing gas exchange or causing lung instability, for safety guideline development.

Strengths

• Developed through expert consensus using the Nominal Group Technique, integrating extensive clinical ICU experience.
• Guidance is supported by review of published animal and clinical studies on APRV and lung physiology.
• Released under a permissive CC BY 4.0 license for broad reuse.

Limitations

• The dataset is a single 234.4 KB PDF document containing textual recommendations, not structured quantitative data.
• As an expert recommendation and position statement, it is not a formal consensus guideline validated by systematic review.
• The scope is limited to APRV settings for adult ARDS and related conditions, not other ventilation modes or patient populations.

Provenance

Source

Gary F. Nieman via figshare.

Collection Method

Expert consensus discussions integrating clinical experience and literature review, using the Nominal Group Technique.

Time Range

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Freshness

Last updated March 25, 2026.

Geography

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